What happens if you take Jardiance at night?

Healthcare professionals recommend taking Jardiance in the morning. However, scientists have investigated what happens if you take Jardiance at night and whether or not it may still be effective.
Jardiance (empagliflozin) is a prescription medication. It helps control your blood sugar levels if you have type 2 diabetes. It also helps to reduce your risk of cardiovascular problems if you also have certain heart conditions. Doctors will prescribe dietary changes and physical activity alongside Jardiance.
blood sugar levels
type 2 diabetes
Jardiance is a sodium-glucose cotransporter-2 (SGLT-2) inhibitor medication. It contains the active ingredient empagliflozin. It lowers your blood sugar levels by helping your kidneys get rid of glucose through your urine.
This article discusses taking Jardiance at night versus in the morning and whether the drug makes you sleepy. It also discusses taking Jardiance twice per day, what happens if you stop taking Jardiance, and more.
Should you take Jardiance at night or in the morning?
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You should always take Jardiance exactly as your doctor instructs. They will prescribe the correct dosage for you. The recommended time to take Jardiance is once daily in the morning, with or without food.
recommended
In 2021, scientists studied whether you should take Jardiance in the morning or the evening. They investigated the drug’s effect on blood sugar levels in 16 participants.
studied
During the study, the participants took one 10-milligram (mg) dose of Jardiance in the evening at 7:00 p.m. The scientists then monitored them for 24 hours and tested their urine and blood.
The participants returned 7 days later and took another 10-mg dose of Jardiance at 9 a.m. Again, the scientists monitored them and performed blood and urine tests.
After analyzing the data, researchers found there were small differences as to when the medication reached peak levels in the morning versus the evening doses. However, there wasn’t a significant difference in the drug’s overall effectiveness, which suggests Jardiance might also work at night.
Still, other factors, such as a person’s individual sleep-wake cycles or some of Jaridance’s side effects, could affect how well the drug works for nighttime use.
Jaridance’s side effects
Despite this research, you should always follow your doctor’s instructions for taking Jardiance. In the United States, this is to take Jardiance in the morning.
You may see guidance from other international sources online with different recommendations. Some may say you can take Jardiance at any time of the day, as long as it’s the same time each day. However, always follow your doctor’s instructions.
other international sources
To manage type 2 diabetes, Jardiance may be used in combination with other medications, such as insulin, metformin, or a drug in the sulfonylurea class (such as glipizide or glimepiride).
insulin
metformin
glipizide
glimepiride
If you are taking multiple medications, your risk of hypoglycemia (low blood sugar) will increase. It may be difficult to know if you are experiencing hypoglycemia while sleeping, which can become life threatening.
hypoglycemia
Jardiance has some other potential side effects that may affect nighttime use, such as nocturia. This condition may cause you to:
nocturia
urinate more often than usual
produce more urine than usual
If you have questions about Jardiance and any of its side effects, be sure to talk with your doctor or pharmacist.
Feeling sleepy or fatigued can be a symptom of some serious Jardiance side effects, including diabetic ketoacidosis (DKA). DKA can be a life threatening complication of type 1 or type 2 diabetes. People with DKA need treatment in the hospital.
diabetic ketoacidosis (DKA)
If you have type 2 diabetes and experience tiredness or sleepiness after taking Jardiance, talk with your doctor about possible causes.
Can you take Jardiance twice per day?
Jardiance was not studied for twice-daily dosing. The dosage of Jardiance is 10 mg once daily in the morning. You can take it with or without food.
studied
Doctors may increase your dosage to 25 mg orally once daily. This is the maximum dosage of Jardiance. You should never take more than your prescribed dosage.
If you have questions about taking Jaridance twice per day, speak with your doctor. Always follow your doctor’s instructions for taking Jardiance.
If you miss a dose of Jardiance, take it as soon as you remember. If it’s close to your next dose, skip the missed dose, and take it at your regularly scheduled time. Do not take two doses at once.
If you have questions about whether you should skip a dose or take it, talk with your doctor or pharmacist.
Does Jardiance lower blood sugar immediately?
Jardiance starts to work approximately 30 to 60 minutes after taking it to lower blood sugar. However, it could take a few days to several weeks to experience the full effects of the drug.
If you have additional questions about how long the drug takes to work, talk with your doctor or pharmacist.
What happens if you stop taking Jardiance?
The half-life of Jardiance is 12.4 hours, so most of the drug will leave your system within 2 days. A half-life is how long it takes for a substance to reduce to half its original amount in your body.
12.4 hours
You should not stop taking Jardiance unless your doctor recommends it. There may be instances where they tell you to stop taking it, such as before you have surgery.
Always follow your doctor’s instructions about stopping Jardiance and when to start taking it again.
Summary
The recommended time to take Jardiance is in the morning. Scientists have investigated taking Jardiance at night.
Although there wasn’t a significant difference in the drug’s overall effectiveness, other factors, such as a person’s individual sleep-wake cycles or some of Jaridance’s side effects, may affect how well the drug works for nighttime use.
Always follow your doctor’s instructions when taking Jardiance. Do not stop taking Jardiance unless your doctor tells you to do so. If you have questions about Jardiance, talk with your doctor or pharmacist.